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1

Standardization Protocols and Optimized Precursor Sets for the Efficient Application of Automated Parallel Synthesis to Lead Optimization: A Mitsunobu Example.

Robert G. Gentles, Dariusz Wodka, David C. Park, Anil Vasudevan

Journal:

Year:

2003

File:

PDF, 134 KB

2003

2

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2

Anil Vasudevan, Dariusz Wodka, Mary K. Verzal, Andrew J. Souers, Ju Gao, Sevan Brodjian, Dennis Fry, Brian Dayton, Kennan C. Marsh, Lisa E. Hernandez, Christopher A. Ogiela, Christine A. Collins, Phil

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

3

Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity

Andrew S. Judd, Andrew J. Souers, Dariusz Wodka, Gang Zhao, Mathew M. Mulhern, Rajesh R. Iyengar, Ju Gao, John K. Lynch, Jennifer C. Freeman, H. Douglas Falls, Sevan Brodjian, Brian D. Dayton, Regina

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 219 KB

english, 2007

4

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3

Andrew J. Souers, Dariusz Wodka, Ju Gao, Jared C. Lewis, Anil Vasudevan, Sevan Brodjian, Brian Dayton, Christopher A. Ogiela, Dennis Fry, Lisa E. Hernandez, Kennan C. Marsh, Christine A. Collins, Phil

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

5

Solid-Phase Synthesis of Benzoxazoles from 3-Nitrotyrosine

Beebe, Xenia, Wodka, Dariusz, Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

6

An efficient method to access 2-substituted benzimidazoles under solvent-free conditions

Ping Lan, F. Anthony Romero, Threshia S. Malcolm, Benjamin D. Stevens, Dariusz Wodka, Gergely M. Makara

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 141 KB

english, 2008

7

The X-ray crystal structure, 13C and 15N NMR spectra of (η5-C5H5)Fe(CO)2 (η1-N-phthalimidato)

Maria Bukowska-Strzyżewska, Anita Tosik, Dariusz Wódka, Janusz Zakrzewski

Journal:

Year:

1994

Language:

english

File:

PDF, 497 KB

english, 1994

8

Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists: Assessment of Potency, Efficacy, and Cardiovascular Safety

Lynch, John K., Freeman, Jennifer C., Judd, Andrew S., Iyengar, Rajesh, Mulhern, Mathew, Zhao, Gang, Napier, James J., Wodka, Dariusz, Brodjian, Sevan, Dayton, Brian D.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 266 KB

english, 2006

9

Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity

Andrew J. Souers, Ju Gao, Dariusz Wodka, Andrew S. Judd, Mathew M. Mulhern, James J. Napier, Michael E. Brune, Eugene N. Bush, Sevan J. Brodjian, Brian D. Dayton, Robin Shapiro, Lisa E. Hernandez, Ken

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 282 KB

english, 2005

10

Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: The effects of chirality on substituted indan-1-ylamines

Andrew J. Souers, Rajesh R. Iyengar, Andrew S. Judd, David W.A. Beno, Ju Gao, Gang Zhao, Michael E. Brune, James J. Napier, Mathew M. Mulhern, John K. Lynch, Jennifer C. Freeman, Dariusz Wodka, Chong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 200 KB

english, 2007

11

An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists

Rajesh R. Iyengar, John K. Lynch, Mathew M. Mulhern, Andrew S. Judd, Jennifer C. Freeman, Ju Gao, Andrew J. Souers, Gang Zhao, Dariusz Wodka, H. Doug Falls, Sevan Brodjian, Brian D. Dayton, Regina M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 211 KB

english, 2007

12

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1

Andrew J. Souers, Dariusz Wodka, Ju Gao, Jared C. Lewis, Anil Vasudevan, Robert Gentles, Sevan Brodjian, Brian Dayton, Christopher A. Ogiela, Dennis Fry, Lisa E. Hernandez, Kennan C. Marsh, Christine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 281 KB

english, 2004

13

Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists

Kym, Philip R., Iyengar, Rajesh, Souers, Andrew J., Lynch, John K., Judd, Andrew S., Gao, Ju, Freeman, Jennifer, Mulhern, Mathew, Zhao, Gang, Vasudevan, Anil, Wodka, Dariusz, Blackburn, Christopher, B

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 102 KB

english, 2005

14

Identification of 2-(4-Benzyloxyphenyl)- N - [1-(2-pyrrolidin-1-yl-ethyl)-1 H -indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity

Souers, Andrew J., Gao, Ju, Brune, Michael, Bush, Eugene, Wodka, Dariusz, Vasudevan, Anil, Judd, Andrew S., Mulhern, Mathew, Brodjian, Sevan, Dayton, Brian, Shapiro, Robin, Hernandez, Lisa E., Marsh,

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 92 KB

english, 2005

15

Standardization Protocols and Optimized Precursor Sets for the Efficient Application of Automated Parallel Synthesis to Lead Optimization: A Mitsunobu Example

Gentles, Robert G., Wodka, Dariusz, Park, David C., Vasudevan, Anil

Journal:

Journal of Combinatorial Chemistry

Year:

2002

Language:

english

File:

PDF, 359 KB

english, 2002

16

Screening for Cardiovascular Safety: A Structure−Activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists

Kym, Philip R., Souers, Andrew J., Campbell, Thomas J., Lynch, John K., Judd, Andrew S., Iyengar, Rajesh, Vasudevan, Anil, Gao, Ju, Freeman, Jennifer C., Wodka, Dariusz, Mulhern, Mathew, Zhao, Gang, W

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 292 KB

english, 2006

17

Hit-to-lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-based Activators of AMP-activated Protein Kinase

Lan, Ping, Romero, F. Anthony, Wodka, Dariusz, Kassick, Andrew J, Dang, Qun, Gibson, Tony, Cashion, Dan, Zhou, Gaochao, Chen, Yuli, Zhang, Xiaoping, Zhang, Aihua, Li, Ying, Trujillo, Maria E., Shao, Q

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 794 KB

english, 2017

18

Synthesis of Fluorinated and Nonfluorinated Tebufenpyrad Analogues for the Study of Anti-angiogenesis MOA

Román, Raquel, Navarro, Antonio, Wodka, Dariusz, Alvim-Gaston, Maria, Husain, Saba, Franklin, Natalie, Simón-Fuentes, Antonio, Fustero, Santos

Journal:

Organic Process Research & Development

Year:

2014

Language:

english

File:

PDF, 2.12 MB

english, 2014

19

Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-N-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Rohde, Jeffrey J., Pliushchev, Marina A., Sorensen, Bryan K., Wodka, Dariusz, Shuai, Qi, Wang, Jiahong, Fung, Steven, Monzon, Katina M., Chiou, William J., Pan, Liping

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 257 KB

english, 2007

20

α-CH Bond Activation of Coordinated Et 2 O via Reaction of PR 3 (R = Ph, Cy) with the Cationic Complex [C 5 Me 5 W(CO) 3 (OEt 2 )] +

Yi, Chae S., Wódka, Dariusz, Rheingold, Arnold L., Yap, Glenn P. A.

Journal:

Organometallics

Year:

1996

Language:

english

File:

PDF, 114 KB

english, 1996

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